Epigenetic regulation of host response to LPS: Causing tolerance while avoiding toll errancy

被引：14

作者：

Arbibe, Laurence

Sansonetti, Philippe J.

机构：

[1] Inst Pasteur, Unite Pathogenie Microbienne Mol, F-75724 Paris 15, France

[2] Inst Pasteur, Unite INSERM 786, F-75724 Paris 15, France

来源：

CELL HOST & MICROBE | 2007年 / 1卷 / 04期

关键词：

D O I：

10.1016/j.chom.2007.05.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Tolerance to lipopolysaccharide (LPS) is part of the host's strategy to avoid harmful excessive inflammation in the presence of Gram-negative commensals and pathogens. Macrophages are the major cells endowed with this property, allowing them to limit expression of proinflarnmatory genes while maintaining efficient antimicrobial functions. In a recent paper, Foster et al. (2007) demonstrate that this subtle balance is established and imprinted via epigenetic regulation.

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页码：244 / 246

页数：3

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