Effect of 6-hydroxydopamine or repeated amphetamine treatment on mesencephalic mRNA levels for AMPA glutamate receptor subunits in the rat

被引：5

作者：

Bardo, MT ^{[1
]}

Robinet, PM

Mattingly, BA

Margulies, JE

机构：

[1] Univ Kentucky, Dept Psychol, Lexington, KY 40506 USA

[2] Morehead State Univ, Dept Psychol, Morehead, KY 40351 USA

[3] Cedars Sinai Med Ctr, Dept Surg, Div Surg Res, Los Angeles, CA 90048 USA

来源：

NEUROSCIENCE LETTERS | 2001年 / 302卷 / 2-3期

关键词：

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor; dopamine; 6-hydroxydopamine; amphetamine; mesencephalon; locomotor activity; sensitization;

D O I：

10.1016/S0304-3940(01)01681-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Expression of alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) subunit mRNAs were assayed in the ventral mesencephalon of rats that received either a unilateral microinjection of the dopamine neurotoxin B-hydroxydopamine (6-OHDA; Experiment 1) or repeated treatment with amphetamine (Experiment 2). GluR2 levels were decreased 1 and 3 days after the lesion, and GluR1 and GluR3 levels also showed a transient decrease at 1 day after the lesion. Repeated amphetamine treatment did not significantly alter GluR1-4 levels measured 30 min after the third or tenth amphetamine injection, even though locomotor sensitization was obtained. Thus, while the present results indicate that AMPA receptor subunits are associated with dopamine-containing cell bodies in the ventral mesencephalon, these transcripts may not be responsible for the development of amphetamine sensitization. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：133 / 136

页数：4

共 15 条

[1] Repeated cocaine alters glutamate receptor subunit levels in the nucleus accumbens and ventral tegmental area of rats that develop behavioral sensitization [J].