Neuroepithelial co-expression of Gbx2 and Otx2 precedes Fgf8 expression in the isthmic organizer

被引：77

作者：

Garda, AL ^{[1
]}

Echevarría, D ^{[1
]}

Martínez, S ^{[1
]}

机构：

[1] Fac Med, Inst Neurociencias, E-03550 Alicante, Spain

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 101卷 / 1-2期

关键词：

secondary organizer; planar induction; isthmic organizer; mid-hindbrain; Gbx2; Otx2; Fgf8; experimental embryology; beads insertion;

D O I：

10.1016/S0925-4773(00)00567-0

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The most studied secondary neural organizer is the isthmic organizer, which is localized at the mid-hindbrain transition of the neural tube and controls the anterior hindbrain and midbrain regionalization. Otx2 and Gbx2 expressions are fundamental for positioning the organizer and the establishment of molecular interactions that induce Fgf8. We present here evidences demonstrating that Otx2 and Gbx2 have an overlapping expression in the isthmic region. This area is the transversal domain where expression of Fgf8 is induced. The Fgf8 protein produced in the isthmus stabilizes and up-regulates Gbx2 expression, which, in turn, down-regulates Otx2 expression. The inductive effect of the Gbx2/Otx2 limit keeps Fgf8 expression stable and thus maintains its positive role in the expression of Pax2, En1,2 and Wnt1. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：111 / 118

页数：8

共 34 条

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