Fertilization defects in sperm from mice lacking fertilinβ

被引：426

作者：

Cho, CH

Bunch, DO

Faure, JE

Goulding, EH

Eddy, EM

Primakoff, P

Myles, DG ^{[1
]}

机构：

[1] Univ Calif Davis, Sect Mol & Cellular Biol, Livermore, CA 95616 USA

[2] NIEHS, Reprod & Dev Toxicol Lab, NIH, Res Triangle Pk, NC 27709 USA

来源：

SCIENCE | 1998年 / 281卷 / 5384期

关键词：

D O I：

10.1126/science.281.5384.1857

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fertilin, a member of the ADAM family, is found on the plasma membrane of mammalian sperm. Sperm from mice tacking fertilin beta were shown to be deficient in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus into the oviduct, and binding to the egg zona pellucida. Egg activation was unaffected. The results are consistent with a direct role of fertilin in sperm-egg plasma membrane interaction. Fertilin could also have a direct role in sperm-zona binding or oviduct migration; alternatively, the effects on these functions could result from the absence of fertilin activity during spermatogenesis.

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页码：1857 / 1859

页数：3

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