Zebrafish mutants as models for congenital ocular disorders in humans

被引：53

作者：

Gross, Jeffrey V. ^{[1
]}

Perkins, Brian D. ^{[2
]}

机构：

[1] Univ Texas Austin, Inst Neurosci, Inst Cell & Mol Biol, Sect Mol Cell & Dev Biol, Austin, TX 78712 USA

[2] Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA

来源：

MOLECULAR REPRODUCTION AND DEVELOPMENT | 2008年 / 75卷 / 03期

关键词：

zebrafish; eye; development; disease;

D O I：

10.1002/mrd.20831

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the last 15 years, the zebrafish has provided an ideal animal model system to study human ocular disorders. Forward genetic screens have identified a number of mutants that serve as excellent models for coloboma, cataracts, and photoreceptor and RPE pathologies. Ongoing screens in several laboratories, utilizing transgenic strains and more advanced screening techniques, as well as the positional cloning of affected loci in many, as yet, unidentified mutants promises to continue this trend for many years to come. © 2007 Wiley-Liss, Inc.

引用

页码：547 / 555

页数：9

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