Direct catalytic synthesis of enantiopure 5-substituted oxazolidinones from racemic terminal epoxides

被引：49

作者：

Bartoli, G ^{[1
]}

Bosco, M ^{[1
]}

Carlone, A ^{[1
]}

Locatelli, M ^{[1
]}

Melchiorre, P ^{[1
]}

Sambri, L ^{[1
]}

机构：

[1] Univ Bologna, Dept Organ Chem A Mangini, I-40136 Bologna, Italy

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 10期

关键词：

D O I：

10.1021/ol050675c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A venerable scaffold for asymmetric synthesis and drug development, chiral 5-substituted oxazolidinones are obtained in almost enantiomerically pure form (up to 99.9% ee) starting from racemic terminal epoxides. The salient features of this process include the very simple and convenient experimental protocol and the employment of a readily accessible catalyst and inexpensive, easily handled starting materials. An enantioconvergent approach for the total conversion of racemic epoxide into a single stereoisomeric oxazolidinone is also described.

引用

页码：1983 / 1985

页数：3

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