Larger than DbI: new structural insights into RhoA activation

被引：29

作者：

Rossman, KL

Sondek, J ^{[1
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2005年 / 30卷 / 04期

关键词：

D O I：

10.1016/j.tibs.2005.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dbl homology (DH) domains are almost always followed immediately by pleckstrin homology (PH) domains in Dbl family proteins, and these DH-PH fragments directly activate GDP-bound Rho GTPases by catalyzing the exchange of GDP for GTP. New crystal structures of the DH-PH domains from leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) and PDZ-RhoGEF bound to RhoA reveal how DH-PH domains cooperate to specifically activate Rho GTPases.

引用

收藏

页码：163 / 165

页数：3

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