Peptide antibiotics: Holy or heretic grails of innate immunity?

被引：51

作者：

Boman, HG

机构：

[1] Department of Microbiology, Stockholm University, Stockholm

[2] Department of Microbiology, University of Stockholm

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1996年 / 43卷 / 05期

关键词：

D O I：

10.1046/j.1365-3083.1996.d01-76.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the last 2 years (1994-95), two symposium volumes and three reviews have been published that were fully devoted to peptide antibiotics (antibacterial peptides or antimicrobial peptides). Since the field has been growing rapidly, this review is largely a follow-up of new results published in the last 2 years. Sequencing of the 16S RNA of the small ribosomal subunit indicate that the microbial world is much larger than generally appreciated. The importance of the natural flora is stressed and its effect on the evolution of peptide antibiotics and immunity in general is discussed.

引用

页码：475 / 482

页数：8

共 51 条

[1] NK-LYSIN, A NOVEL EFFECTOR PEPTIDE OF CYTOTOXIC T-CELLS AND NK-CELLS - STRUCTURE AND CDNA CLONING OF THE PORCINE FORM, INDUCTION BY INTERLEUKIN-2, ANTIBACTERIAL AND ANTITUMOR-ACTIVITY [J].