Selective halogen-lithium exchange reaction of bromine-substituted 25,26,27,28-tetrapropoxycalix[4]arene

被引：81

作者：

Larsen, M

Jorgensen, M

机构：

[1] Department of Solid State Physics, Materials Chemistry, RISØ National Laboratory, DK-4000 Roskilde

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 19期

关键词：

D O I：

10.1021/jo9609440

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methods are described for the selective bromine-lithium exchange reaction of bromine-substituted calix[4]arenes with either n-BuLi or t-BuLi in THF. Quenching of the lithiated calix[4]arenes with MeOH, D2O, CH3SSCH3, B(OCH3)(3), DMF, or CO2 as electrophiles resulted in 5-monosubstituted, 5,17-disubstituted, or 5,11,17,23-tetrasubstituted calix[4]arenes with H, D, SCH3, B(OH)(2), CHO, or COOH functionalities.

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页码：6651 / 6655

页数：5

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