Fluorescence studies of DNA and RNA structure and dynamics

被引：116

作者：

Millar, DP

机构：

[1] Scripps Research Institute, Department of Molecular Biology, MB-19, San Diego, CA 92037

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1996年 / 6卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(96)80050-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fluorescence spectroscopy is increasingly being used as a technique for probing the structure and dynamics of nucleic acids. Recently, fluorescence methods have been used to elucidate the three-dimensional arrangement of complex DNA and RNA structures, characterize structural perturbations resulting from base bulges in helices and junctions, determine helical handedness in solution, and analyze the protein-induced melting of DNA.

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页码：322 / 326

页数：5

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