The effect of zearalenone on some enzymatic parameters in rabbits

The effects of low (10 mug/kg b.w.) and high (100 mug/kg b.w.) doses of mycotoxin-zearalenone on selected blood serum enzyme activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), and total lactatedehydrogenase (LD) of rabbits were studied. The toxin was administered orally for 14 days. In the experimental group E, (10]Ig:kg b.w.), a significant increase in ALP activity was observed at 168 and 336 h during the experiment. In the 100 mug zearalenone sera (group E), significant increases in activities of AST. ALT, ALP. GGT. and LD were observed at 168 and 336 h, indicating possible liver toxicity due to chronic effects of the toxin. (C) 2001 Elsevier Science Ireland Ltd. Ail rights reserved.