Towards a dynamic approach of experimental parkinsonism

被引：1

作者：

Bezard, E ^{[1
]}

Boraud, T ^{[1
]}

Imbert, C ^{[1
]}

Dovero, S ^{[1
]}

Bioulac, B ^{[1
]}

Gross, CE ^{[1
]}

机构：

[1] Univ Bordeaux 2, Neurophysiol Lab, CNRS, UMR 5543, F-33076 Bordeaux, France

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1998年 / 22卷 / 08期

关键词：

monkey; mouse; MPTP; slow evolution of disease;

D O I：

10.1016/S0278-5846(98)00072-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. In order to mimic the slow and continuous evolution of Parkinson's disease, a chronic model of parkinsonism in monkeys and mice has been developed. 2. Seven monkeys were daily treated with low-dose of MPTP administered intravenously until their clinical scores reached a value of 30-35% of the maximal score. MPTP treatment was stopped at D15.5 +/- 1. 3. The evolution of clinical signs resembles Parkinson's disease and monkeys showed rigidity, akinesia and resting tremor which is not alleviated by L-Dopa treatment. 4. 90 mice were daily treated with low-dose of MPTP during 20 days. Every two days, 8 individuals were euthanized and their mesencephalon processed for tyrosine-hydroxylase immunohistochemistry. The kinetics of nigral degeneration evolves with an exponential decay. 5. This chronic model of MPTP treatment so could be of great interest for study of the dynamic physiopathological changes which occur in Parkinson's disease.

引用

页码：1317 / 1329

页数：13

共 46 条

[1] PARKINSONS-DISEASE - PATHOPHYSIOLOGY [J].