Optimal self-referenced sensing using long- and short-range surface plasmons

被引：56

作者：

Hastings, J. T. ^{[1
]}

Guo, J. ^{[1
]}

Keathley, P. D. ^{[1
]}

Kumaresh, P. B. ^{[1
]}

Wei, Y. ^{[2
]}

Law, S. ^{[2
]}

Bachas, L. G. ^{[2
]}

机构：

[1] Univ Kentucky, Dept Elect & Comp Engn, Lexington, KY 40506 USA

[2] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA

来源：

OPTICS EXPRESS | 2007年 / 15卷 / 26期

关键词：

D O I：

10.1364/OE.15.017661

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Dual-mode surface-plasmon resonance (SPR) sensors use both long- and short-range surface plasmon waves to differentiate surface binding interactions from interfering bulk effects. We have optimized the design of these sensors for minimum surface limit of detection (LOD) using a Cramer-Rao lower bound for spectral shift estimation. Despite trade-offs between resonance width, minimum reflectivity, and sensitivity for the two modes, a range of reasonable design parameters provides nearly optimal performance. Experimental verification using biotin-streptavidin binding as a model system reveals that sensitivity and LOD for dual-mode sensors remains competitive with single-mode sensors while compensating for bulk effects. (C) 2007 Optical Society of America.

引用

页码：17661 / 17672

页数：12

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