Caspase 7-induced cleavage of kinectin in apoptotic cells

被引：28

作者：

Machleidt, T ^{[1
]}

Geller, P ^{[1
]}

Schwandner, R ^{[1
]}

Scherer, G ^{[1
]}

Krönke, M ^{[1
]}

机构：

[1] Univ Kiel, Inst Immunol, D-24105 Kiel, Germany

来源：

FEBS LETTERS | 1998年 / 436卷 / 01期

关键词：

kinectin; caspase; 7; apoptosis;

D O I：

10.1016/S0014-5793(98)01095-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kinectin has been characterized as the first known receptor for the molecular motor kinesin, which is critically involved in microtubule-based vesicle transport and membrane trafficking. Here we identify kinectin as a target for caspase-mediated proteolysis during apoptosis, Treatment of cells with diverse apoptotic stimuli including TNF, anti-Fas, anticancer drugs, gamma-radiation or ceramide leads to rapid proteolytic cleavage of the 160-kDa form of kinectin to a 120-kDa fragment. Evidence is provided that kinectin cleavage is mediated by caspase 7. (C) 1998 Federation of European Biochemical Societies.

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收藏

页码：51 / 54

页数：4

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