Relationship between joint shape and the development of osteoarthritis

被引：61

作者：

Baker-LePain, Julie C. ^{[2
]}

Lane, Nancy E. ^{[1
]}

机构：

[1] Univ Calif Davis, Med Ctr, Dept Internal Med, Ctr Healthy Aging, Sacramento, CA 95817 USA

[2] Univ Calif San Francisco, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN RHEUMATOLOGY | 2010年 / 22卷 / 05期

关键词：

bone; geometry; hip; joint shape; osteoarthritis; RADIOGRAPHIC HIP OSTEOARTHRITIS; ELDERLY WHITE WOMEN; FEMORAL-HEAD SHAPE; NECK-SHAFT ANGLE; ARTICULAR-CARTILAGE; SYMPTOMATIC OSTEOARTHRITIS; OSTEOPOROTIC FRACTURES; INTERLEUKIN-4; RECEPTOR; SUSCEPTIBILITY LOCUS; ACETABULAR DYSPLASIA;

D O I：

10.1097/BOR.0b013e32833d20ae

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review To present an updated summary of the relationship between joint shape and the development of osteoarthritis, with a particular focus on osteoarthritis of the hip. Recent findings Osteoarthritis of the hip is highly heritable, with a genetic contribution estimated at 60%. Among the genes that have been linked to this disease are several that are involved in the development and maintenance of joint shape, including members of the Wingless (Wnt) and the bone morphogenetic protein (BMP) family. Several features of hip joint architecture, such as acetabular dysplasia, pistol grip deformity, wide femoral neck, altered femoral neck-shaft angle, appear to play an important role in the pathogenesis of osteoarthritis and may predate the development of osteoarthritis by decades. Summary Gene-environment interactions play a crucial role in the development of osteoarthritis. The architecture of joint shape is determined by a complex sequence spanning embryonic, childhood, and adult life and contributes to the pathogenesis of osteoarthritis.

引用

页码：538 / 543

页数：6

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