pH-controllable drug release using hydrogel encapsulated mesoporous silica

被引：127

作者：

Song, S.-W. ^{[1
]}

Hidajat, K. ^{[1
]}

Kawi, S. ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 119260, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 42期

关键词：

D O I：

10.1039/b707626f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amine-functionalized mesoporous SBA-15 silica loaded with bovine serum albumin (BSA) has been successfully encapsulated with a thin layer coating of poly(acrylic acid) PAA, with the entrapped BSA being released from the PAA- encapsulated SBA-15 at the higher pH value of 7.4 rather than at the lower pH value of 1.2. This novel drug delivery system has a potential application in the release of protein drug to the site of higher pH value, such as small intestine or colon.

引用

页码：4396 / 4398

页数：3

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