Topical inhibition of oral carcinoma cell with polymer delivered celecoxib

被引：21

作者：

Wang, Z ^{[1
]}

Polavaram, R ^{[1
]}

Shapshay, SM ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Boston Med Ctr, Dept Otolaryngol Head & Neck Surg, Boston, MA 02118 USA

来源：

CANCER LETTERS | 2003年 / 198卷 / 01期

关键词：

topical treatment; polymer; oral cancer; celecoxib;

D O I：

10.1016/S0304-3835(03)00272-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Celecoxib has a potential role for oral cancer chemoprevention but its systemic side effects are a concern. Topical chemoprevention is a promising way to reduce the toxicity. This study was designed to determine whether topical application of polymer delivered celecoxib would have an inhibitory effect on human oral carcinoma cells. Seventeen nude mice were intradermally inoculated with the carcinoma cells, and then were divided into control and treatment groups. Tumor growth was measured for 15 days, at which significant difference was found between two groups (P < 0.001). This study indicates a potential role of polymer film delivered celecoxib for topical inhibition of oral cancer. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：53 / 58

页数：6

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