Results of radiation therapy for hypopharyngeal carcinoma: Impact of accelerated hyperfractionation on prognosis

被引:6
作者
Akimoto, T
Mitsuhashi, N
Sakurai, H
Takahashi, T
Yamakawa, M
Hayakawa, K
Kiryu, Y
Niibe, H
机构
[1] Dept. of Radiol. and Radiat. Oncol., Gunma University, School of Medicine, Maebashi
[2] Department of Public Health, Gunma University, School of Medicine, Maebashi
[3] Dept. of Radiol. and Radiat. Oncol., Gunma University, School of Medicine, Maebashi, Gunma 371, 39-22
关键词
hypopharyngeal carcinoma; accelerated hyperfractionation; radiation therapy;
D O I
10.1093/oxfordjournals.jjco.a023202
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We reviewed the results of treatment in 52 patients with hypopharyngeal carcinoma who underwent radical radiation therapy using a two-fractionation scheme - conventional fractionation (CF) and accelerated hyperfractionation (AHF) - in order to evaluate the impact of the fractionation scheme on prognosis. The 5-year survival rate for the 52 patients was 19.5%, and a significantly better rate was obtained with AHF (44.4%) than with CF (12.4%). Of 27 patients who showed a complete response (CR), a higher CR rate (61%) was achieved with AHF than with CF (47%). A similar trend was also observed for T3 and T4 tumors (55% with AHF vs. 36% with CF). Multivariate analysis demonstrated that neck node status was a significant factor related to local control, and that local response and the fractionation scheme employed were significant prognostic factors for survival. The recurrence rate and recurrence within the radiation field in the AHF group was lower than in the CF group (27% vs. 50%), although the time to recurrence in the two groups did not differ greatly. Voice preservation was achieved in 20% of the patients. Considering the better survival and local control rate compared with conventional fractionation, accelerated hyperfractionation seems a preferable treatment for hypopharyngeal carcinoma.
引用
收藏
页码:169 / 174
页数:6
相关论文
共 27 条
[1]  
AHMAD K, 1984, CANCER, V53, P2091, DOI 10.1002/1097-0142(19840515)53:10<2091::AID-CNCR2820531016>3.0.CO
[2]  
2-R
[3]   RESULTS OF RADICAL RADIOTHERAPEUTIC TREATMENT OF CARCINOMA OF THE PYRIFORM SINUS - EXPERIENCE OF THE INSTITUT-CURIE [J].
BATAINI, P ;
BRUGERE, J ;
BERNIER, J ;
JAULERRY, CH ;
PICOT, C ;
GHOSSEIN, NA .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1982, 8 (08) :1277-1286
[4]  
COX DR, 1972, J R STAT SOC B, V34, P187
[5]   INTERFRACTION INTERVAL IS A MAJOR DETERMINANT OF LATE EFFECTS, WITH HYPERFRACTIONATED RADIATION-THERAPY OF CARCINOMAS OF UPPER RESPIRATORY AND DIGESTIVE TRACTS - RESULTS FROM RADIATION-THERAPY ONCOLOGY GROUP PROTOCOL 8313 [J].
COX, JD ;
PAJAK, TF ;
MARCIAL, VA ;
COIA, L ;
MOHIUDDIN, M ;
FU, KK ;
SELIM, H ;
RUBIN, P ;
ORTIZ, H .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1991, 20 (06) :1191-1195
[6]   DOSE-RESPONSE FOR LOCAL-CONTROL WITH HYPERFRACTIONATED RADIATION-THERAPY IN ADVANCED CARCINOMAS OF THE UPPER AERODIGESTIVE TRACTS - PRELIMINARY-REPORT OF RADIATION-THERAPY ONCOLOGY GROUP PROTOCOL 83-13 [J].
COX, JD ;
PAJAK, TF ;
MARCIAL, VA ;
HANKS, GE ;
MOHIUDDIN, M ;
FU, KK ;
BYHARDT, RW ;
RUBIN, P .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1990, 18 (03) :515-521
[7]   SPLIT-COURSE ACCELERATED THERAPY IN HEAD AND NECK-CANCER - AN ANALYSIS OF TOXICITY [J].
DELANEY, GP ;
FISHER, RJ ;
SMEE, RI ;
HOOK, C ;
BARTON, MB .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1995, 32 (03) :763-768
[8]   COMBINED THERAPY FOR PYRIFORM SINUS CANCER USING POSTOPERATIVE IRRADIATION [J].
DONALD, PJ ;
HAYES, HR ;
DHALIWAL, R .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1980, 88 (06) :738-744
[9]   CANCER OF THE PIRIFORM SINUS - TREATMENT BY RADIATION-THERAPY ALONE AND WITH SURGERY [J].
DUBOIS, JB ;
GUERRIER, B ;
DIRUGGIERO, JM ;
POURQUIER, H .
RADIOLOGY, 1986, 160 (03) :831-836
[10]  
EISBACH KJ, 1977, LARYNGOSCOPE, V87, P1904