A new focus of cutaneous leishmaniasis due to Leishmania amazonensis in a Sub Andean region of Bolivia

被引：23

作者：

Martínez, E

Le Pont, F

Torrez, M

Tellería, J

Vargas, F

Muñoz, M

De Doncker, S

Dujardin, JC

Dujardin, JP

机构：

[1] CC Sanjinez, Inst Boliviano Biol Altura, La Paz, Bolivia

[2] ORSTOM La Paz, La Paz, Bolivia

[3] Inst Trop Med Prince Leopold, B-2000 Antwerp, Belgium

来源：

ACTA TROPICA | 1998年 / 71卷 / 02期

关键词：

cutaneous leishmaniasis; Leishmania mexicana complex; L-amazonensis; multilocus enzyme electrophoresis; orthogonal field alternated gel electrophoresis; Bolivia;

D O I：

10.1016/S0001-706X(98)00049-7

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

We detected a new outbreak focus with high incidence of cutaneous leishmaniasis in the Sub Andean region of La Paz. This area was never considered previously as an endemic zone of leishmaniasis. Leishmania stocks from human lesions were isolated: three stocks were explored by pulse field gradient electrophoresis, showing evidence for their affiliation to the L. mexicana complex. Eight stocks were submitted to isoenzyme electrophoresis and compared with five reference strains: L. amazonensis, L. braziliensis, L. chagasi, L. mexicana and L. pifanoi. Close genetic proximity was evidenced between newly isolated parasites and the reference stock of L. amazonensis, whereas high divergence was observed between them and either the L. pifanoi, L. mexicana, L. braziliensis and L. chagasi reference strains. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：97 / 106

页数：10

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