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Reelin glycoprotein: structure, biology and roles in health and disease

被引：176
作者：
Fatemi, SH [1 ]
机构：
[1] Univ Minnesota, Sch Med, Dept Psychiat, Div Neurosci Res, Minneapolis, MN 55455 USA
来源：
MOLECULAR PSYCHIATRY | 2005年 / 10卷 / 03期
关键词：
reelin; schizophrenia; autism; reeler mouse;
D O I：
10.1038/sj.mp.4001613
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Reelin glycoprotein is a secretory serine protease with dual roles in mammalian brain: embryologically, it guides neurons and radial glial cells to their corrected positions in the developing brain; in adult brain, Reelin is involved in a signaling pathway which underlies neurotransmission, memory formation and synaptic plasticity. Disruption of Reelin signaling pathway by mutations and selective hypermethylation of the Reln gene promoter or following various pre- or postnatal insults may lead to cognitive deficits present in neuropsychiatric disorders like autism or schizophrenia.
引用
收藏
页码：251 / 257
页数：7
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