The structure and function of platelet-activating factor acetylhydrolases

被引:25
作者
Derewenda, ZS
Derewenda, U
机构
[1] Univ Virginia, Hlth Sci Ctr, Dept Mol Physiol, Charlottesville, VA 22906 USA
[2] Univ Virginia, Hlth Sci Ctr, Dept Biol Phys, Charlottesville, VA 22906 USA
[3] Univ Virginia, Hlth Sci Ctr, Ctr Struct Biol, Charlottesville, VA 22906 USA
关键词
platelet-activating factor; acetylhydrolase; alpha/beta hydrolase; phospholipase A(2); molecular modelling;
D O I
10.1007/s000180050172
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Platelet-activating factor acetylhydrolases (PAF-AHs, EC 3.1.1.47) constitute a unique and biologically important family of phospholipase A(2)s. They are related to neither the well-characterized secretory nor cytosolic PLA(2)s, and unlike them do not require Ca2+ for catalytic activity. The distinguishing property of PAF-AHs is their unique substrate specificity: they act on the phospholipid platelet-activating factor (PAF), and in some cases on proinflammatory polar phospholipids, from which they remove a short acyl moiety - acetyl in the ease of PAF - located at the sn-2 position. Because PAF is found both in the plasma and in the cytosol of many tissues, PAF-acetylhydrolases are equally widely distributed in an animal organism. Recent crystallographic studies shed new light on the complex structure-function relationships in PAF-AHs.
引用
收藏
页码:446 / 455
页数:10
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