A novel linear plasmid mediates flagellar variation in Salmonella Typhi

被引：49

作者：

Baker, Stephen ^{[1
]}

Hardy, Jonathan

Sanderson, Kenneth E.

Quail, Michael

Goodhead, Ian

Kingsley, Robert A.

Parkhill, Julian

Stocker, Bruce

Dougan, Gordon

机构：

[1] Wellcome Trust Sanger Inst, Hinxton, Cambs, England

[2] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA

[3] Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada

来源：

PLOS PATHOGENS | 2007年 / 3卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1371/journal.ppat.0030059

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Unlike the majority of Salmonella enterica serovars, Salmonella Typhi (S. Typhi), the etiological agent of human typhoid, is monophasic. S. Typhi normally harbours only the phase 1 flagellin gene (fliC), which encodes the H:d antigen. However, some S. Typhi strains found in Indonesia express an additional flagellin antigen termed H:z66. Molecular analysis of H:z66+ S. Typhi revealed that the H:z66 flagellin structural gene (fljB(z66)) is encoded on a linear plasmid that we have named pBSSB1. The DNA sequence of pBSSB1 was determined to be just over 27 kbp, and was predicted to encode 33 coding sequences. To our knowledge, pBSSB1 is the first non-bacteriophage-related linear plasmid to be described in the Enterobacteriaceae.

引用

收藏

页码：605 / 610

页数：6

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