Murine models of ulcerative colitis

被引：3

作者：

Flynn, C

Levine, J

Rosenberg, DW

机构：

[1] Univ Connecticut, Ctr Hlth, Ctr Mol Med, Farmington, CT 06030 USA

[2] Univ Connecticut, Ctr Hlth, Dept Med, Div Gastroenterol, Farmington, CT 06030 USA

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2003年 / 26卷 / 06期

关键词：

ulcerative colitis; murine models; colon; cancer; inflammation;

D O I：

10.1007/BF02976857

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ulcerative colitis (UC) is an inflammatory bowel disease of unknown etiology limited to the large intestine. The disease is prevalent in industrial societies and is associated with specific ethnic populations. A number of murine models, each focused on distinct aspects of the disease process, were developed over the past 20 years to further our understanding of the pathogenesis of UC. These models have been and remain our best resource for the study of the disorder as a result of their homology to human UC and the ease in which they can be manipulated and examined. This review examines and distills what has been learned from these models and how this information is related back to human UC.

引用

收藏

页码：433 / 440

页数：8

相关论文

共 41 条

[1] Cytokine mRNA expression in intestinal tissue of interleukin-2 deficient mice with bowel inflammation [J].

Autenrieth, IB ;

Bucheler, N ;

Bohn, E ;

Heinze, G ;

Horak, I .

GUT, 1997, 41 (06) :793-800

[2]

Brandwein SL, 1997, J IMMUNOL, V159, P44

[3] Helicobacter-induced inflammatory bowel disease in IL-10-and T cell-deficient mice [J].

Burich, A ;

Hershberg, R ;

Waggie, K ;

Zeng, WP ;

Brabb, T ;

Westrich, G ;

Viney, JL ;

Maggio-Price, L .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2001, 281 (03) :G764-G778

[4] CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice:: Increased T helper cell type 1 response and ability to transfer disease [J].

Cong, YZ ;

Brandwein, SL ;

McCabe, RP ;

Lazenby, A ;

Birkenmeier, EH ;

Sundberg, JP ;

Elson, CO .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (06) :855-864

[5] THE 3 MOUSE MULTIDRUG RESISTANCE (MDR) GENES ARE EXPRESSED IN A TISSUE-SPECIFIC MANNER IN NORMAL MOUSE-TISSUES [J].

CROOP, JM ;

RAYMOND, M ;

HABER, D ;

DEVAULT, A ;

ARCECI, RJ ;

GROS, P ;

HOUSMAN, DE .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (03) :1346-1350

[6] Lack of oral tolerance but oral priming for contact sensitivity to dinitrofluorobenzene in major histocompatibility complex class II-deficient mice and in CD4(+) T cell-depleted mice [J].

Desvignes, C ;

Bour, H ;

Nicolas, JF ;

Kaiserlian, D .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (08) :1756-1761

[7]

Ehrhardt RO, 1997, J IMMUNOL, V158, P566

[8]

Elson C O, 2000, Int Rev Immunol, V19, P63, DOI 10.3109/08830180009048390

[9] ULCERATIVE-COLITIS AND CROHNS-DISEASE - A COMPARISON OF THE COLORECTAL-CANCER RISK IN EXTENSIVE COLITIS [J].

GILLEN, CD ;

WALMSLEY, RS ;

PRIOR, P ;

ANDREWS, HA ;

ALLAN, RN .

GUT, 1994, 35 (11) :1590-1592

[10] DEPLETION OF CD4+ T-CELLS IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II DEFICIENT MICE [J].

GRUSBY, MJ ;

JOHNSON, RS ;

PAPAIOANNOU, VE ;

GLIMCHER, LH .

SCIENCE, 1991, 253 (5026) :1417-1420

← 1 2 3 4 5 →