High circulating frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4+ T cells in patients with HTLV-1-associated neurological disease

被引：49

作者：

Goon, PKC

Igakura, T

Hanon, E

Mosley, AJ

Asquith, B

Gould, KG

Taylor, GP

Weber, JN

Bangham, CRM

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Immunol, London W2 1PG, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Genitourinary Med & Communicable Dis, London W2 1PG, England

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 17期

关键词：

D O I：

10.1128/JVI.77.17.9716-9722.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Significantly higher frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4(+) T cells were present in the peripheral blood mononuclear cells of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients than in those of asymptomatic carriers with similar provirus loads. The data suggest that HTLV-1-specific CD4(+) T cells play a role in the pathogenesis of HAM/TSP.

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页码：9716 / 9722

页数：7

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