Redox-operated genetic switches: the SoxR and OxyR transcription factors

被引：302

作者：

Pomposiello, PJ ^{[1
]}

Demple, B ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Canc Cell Biol, Boston, MA 02115 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2001年 / 19卷 / 03期

关键词：

D O I：

10.1016/S0167-7799(00)01542-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two redox-responsive transcription regulators have been well defined in Escherichia coli and serve as paradigms of redox-operated genetic switches. SoxR contains iron-sulfur centers that activate the protein when they are one-electron oxidized, or nitrosylated by nitric oxide. OxyR contains a pair of redox-active cysteine residues that activate the protein when they are oxidized to form a disulfide bond.

引用

页码：109 / 114

页数：6

共 31 条

[1] The Escherichia coli OxyS regulatory RNA represses fhlA translation by blocking ribosome binding
Altuvia, S
Zhang, AX
Argaman, L
Tiwari, A
Storz, G
[J]. EMBO JOURNAL, 1998, 17 (20) : 6069 - 6075
[2] MOLECULAR CHARACTERIZATION OF THE SOXRS GENES OF ESCHERICHIA-COLI - 2 GENES CONTROL A SUPEROXIDE STRESS REGULON
AMABILECUEVAS, CF
DEMPLE, B
[J]. NUCLEIC ACIDS RESEARCH, 1991, 19 (16) : 4479 - 4484
[3] Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol -: disulfide status
Åslund, F
Zheng, M
Beckwith, J
Storz, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (11) : 6161 - 6165
[4] Cysteine-to-alanine replacements in the Escherichia coli SoxR protein and the role of the [2Fe-2S] centers in transcriptional activation
Bradley, TM
Hidalgo, E
Leautaud, V
Ding, H
Demple, B
[J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (08) : 1469 - 1475
[5] POSTTRANSCRIPTIONAL REPRESSION OF ESCHERICHIA-COLI OMPF PROTEIN IN RESPONSE TO REDOX STRESS - POSITIVE CONTROL OF THE MICF ANTISENSE RNA BY THE SOXRS LOCUS
CHOU, JH
GREENBERG, JT
DEMPLE, B
[J]. JOURNAL OF BACTERIOLOGY, 1993, 175 (04) : 1026 - 1031
[6] In vivo kinetics of a redox-regulated transcriptional switch
Ding, HG
Demple, B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (16) : 8445 - 8449
[7] The redox state of the [2Fe-2S] clusters in SoxR protein regulates its activity as a transcription factor
Ding, HG
Hidalgo, E
Demple, B
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (52) : 33173 - 33175
[8] SoxR, a [2Fe-2S] transcription factor, is active only in its oxidized form
Gaudu, P
Weiss, B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (19) : 10094 - 10098
[9] Flavodoxin mutants of Escherichia coli K-12
Gaudu, P
Weiss, B
[J]. JOURNAL OF BACTERIOLOGY, 2000, 182 (07) : 1788 - 1793
[10] Regulation of the soxRS oxidative stress regulon - Reversible oxidation of the Fe-S centers of SoxR in vivo
Gaudu, P
Moon, N
Weiss, B
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (08) : 5082 - 5086

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