Expression of specific white adipose tissue genes in denervation-induced skeletal muscle fatty degeneration

被引：86

作者：

Dulor, JP

Cambon, B

Vigneron, P

Reyne, Y

Nouguès, J

Casteilla, L

Bacou, F

机构：

[1] Ecole Natl Super Agron Montpellier, UFR Prod Anim, F-34060 Montpellier 1, France

[2] INRA, Lab Differenciat Cellulaire & Croissance, F-34060 Montpellier, France

[3] Univ Rangueil, CNRS, UPRESA 5018, F-31403 Toulouse 4, France

来源：

FEBS LETTERS | 1998年 / 439卷 / 1-2期

关键词：

muscle degeneration; denervation; skeletal muscle; white adipose tissue; ob gene; rabbit;

D O I：

10.1016/S0014-5793(98)01216-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Denervation of skeletal muscle results in rapid atrophy with loss of contractile mass and/or progressive degeneration of muscle fibers which are replaced to a greater or lesser degree by connective and fatty tissues. In this study, we show that denervated rabbit muscles are transformed into a white adipose tissue, depending on their fiber types. This tissue does express LPL, G3PDH and particularly the ob gene, a white adipose tissue-specific marker, and does not express the brown adipose tissue molecular marker UCP1 mRNA. (C) 1998 Federation of European Biochemical Societies.

引用

页码：89 / 92

页数：4

共 36 条

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ACETYLCHOLINESTERASE FORMS IN FAST AND SLOW RABBIT MUSCLE [J].