Chloroquine inhibits HIV-1 replication in human peripheral blood lymphocytes

被引：31

作者：

Pardridge, WM ^{[1
]}

Yang, J ^{[1
]}

Diagne, A ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90095 USA

来源：

IMMUNOLOGY LETTERS | 1998年 / 64卷 / 01期

关键词：

chloroquine; human immunodeficiency deficiency virus; DNA replication; human lymphocytes;

D O I：

10.1016/S0165-2478(98)00096-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chloroquine has inhibitory effects on human immunodeficiency deficiency virus (HIV)-1 replication in human lymphocytes with an ED50 of 15 mu M, which approximates the chloroquine plasma concentration generated in the acute treatment of malaria. Chloroquine has a parallel inhibitory effect on DNA replication in human lymphocytes, although the inhibitory effect on DNA replication is not as pronounced as is the drug inhibition of HIV-1 replication in the cells. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：45 / 47

页数：3

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