Transcriptional profiling of mouse liver in response to chronic heat stress

被引：24

作者：

Bhusari, S. ^{[1
]}

Hearne, L. B.

Spiers, D. E. ^{[1
]}

Lamberson, W. R. ^{[1
]}

Antoniou, E. ^{[1
]}

机构：

[1] Div Anim Sci, Columbia, MO 65211 USA

来源：

JOURNAL OF THERMAL BIOLOGY | 2008年 / 33卷 / 03期

关键词：

DNA microarray; chronic heat stress; mice;

D O I：

10.1016/j.jtherbio.2008.01.001

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mice were used to study the effects of chronic heat stress on hepatic gene expression. Twenty-five mice were allocated to either chronic heat stress (34 degrees C) or control (24 degrees C) conditions for a period of 2 weeks from 47 to 60 d of age. Nineteen genes differentially expressed in liver were identified using DNA microarrays. Genes involved in the anti-oxidant pathway and metabolism were up-regulated. Genes involved in generation of reactive oxygen radicals and mitochondrial expressed genes were down-regulated. Enzyme activity measurements confirmed the array results. Mice exposed to chronic heat stress showed signs of increased oxidative stress in liver cells. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：157 / 167

页数：11

共 31 条

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