The complex myeloid network of the liver with diverse functional capacity at steady state and in inflammation

被引：70

作者：

Eckert, Christoph ^{[1
]}

Klein, Niklas ^{[1
]}

Kornek, Miroslaw ^{[1
]}

Lukacs-Kornek, Veronika ^{[1
]}

机构：

[1] Univ Saarland, Med Ctr, Dept Med 2, D-66424 Homburg, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷

关键词：

dendritic cells; Kupffer cells; liver fibrosis; NASH; inflammatory monocytes; PLASMACYTOID DENDRITIC CELLS; ANTIGEN-PRESENTING CELLS; HEPATIC STELLATE CELLS; REGULATORY T-CELLS; MONONUCLEAR PHAGOCYTE SYSTEM; TISSUE-RESIDENT MACROPHAGES; TRANSCRIPTION FACTOR ZDC; KUPFFER CELLS; NONALCOHOLIC STEATOHEPATITIS; MURINE LIVER;

D O I：

10.3389/fimmu.2015.00179

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

In recent years, it has been an explosion of information regarding the role of various myeloid cells in liver pathology. Macrophages and dendritic cell (DC) play crucial roles in multiple chronic liver diseases such as fibrosis and non-alcoholic fatty liver disease (NAFLD). The complexity of myeloid cell populations and the missing exclusive marker combination make the interpretation of the data often extremely difficult. The current review aims to summarize the multiple roles of macrophages and DCs in chronic liver diseases, especially pointing out how these cells influence liver immune and parenchymal cells thereby altering liver function and pathology. Moreover, the review outlines the currently known marker combinations for the identification of these cell populations for the study of their role in liver immunology.

引用

页数：11

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