Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma

被引：205

作者：

Xu, Xia ^{[1
]}

Rock, Jason R. ^{[2
]}

Lu, Yun ^{[3
]}

Futtner, Christopher ^{[1
]}

Schwab, Brian ^{[1
]}

Guinney, Justin ^{[4
]}

Hogan, Brigid L. M. ^{[2
]}

Onaitis, Mark W. ^{[1
]}

机构：

[1] Duke Univ, Dept Surg, Durham, NC 27710 USA

[2] Duke Univ, Dept Cell Biol, Durham, NC 27710 USA

[3] Tsingua Univ, Dept Toxicol, Beijing 100084, Peoples R China

[4] Sage Bionetworks, Seattle, WA 98109 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2012年 / 109卷 / 13期

关键词：

STEM-CELLS; MOUSE MODELS; CANCER; MUTATIONS; PROGRESSION; EXPRESSION; ONCOGENES; ALVEOLAR; PATHWAY; AIRWAY;

D O I：

10.1073/pnas.1112499109

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Identifying the cells of origin of lung cancer may lead to new therapeutic strategies. Previous work has focused upon the putative bronchoalveolar stem cell at the bronchioalveolar duct junction as a cancer cell of origin when a codon 12 K-Ras mutant is induced via adenoviral Cre inhalation. In the present study, we use two "knock-in" Cre-estrogen receptor alleles to inducibly express K-RasG12D in CC10(+) epithelial cells and Sftpc(+) type II alveolar cells of the adult mouse lung. Analysis of these mice identifies type II cells, Clara cells in the terminal bronchioles, and putative bronchoalveolar stemcells as cells of origin for K-Ras-induced lung hyperplasia. However, only type II cells appear to progress to adenocarcinoma.

引用

页码：4910 / 4915

页数：6

共 23 条

[1]

BELINSKY SA, 1992, CANCER RES, V52, P3164

[2]

BOS JL, 1989, CANCER RES, V49, P4682

[3]

Brose MS, 2002, CANCER RES, V62, P6997

[4]

Cooper CA, 1997, J PATHOL, V181, P401, DOI 10.1002/(SICI)1096-9896(199704)181:4<401::AID-PATH799>3.0.CO

[5]

2-Y

[6] Somatic mutations affect key pathways in lung adenocarcinoma [J].

Ding, Li ;

Getz, Gad ;

Wheeler, David A. ;

Mardis, Elaine R. ;

McLellan, Michael D. ;

Cibulskis, Kristian ;

Sougnez, Carrie ;

Greulich, Heidi ;

Muzny, Donna M. ;

Morgan, Margaret B. ;

Fulton, Lucinda ;

Fulton, Robert S. ;

Zhang, Qunyuan ;

Wendl, Michael C. ;

Lawrence, Michael S. ;

Larson, David E. ;

Chen, Ken ;

Dooling, David J. ;

Sabo, Aniko ;

Hawes, Alicia C. ;

Shen, Hua ;

Jhangiani, Shalini N. ;

Lewis, Lora R. ;

Hall, Otis ;

Zhu, Yiming ;

Mathew, Tittu ;

Ren, Yanru ;

Yao, Jiqiang ;

Scherer, Steven E. ;

Clerc, Kerstin ;

Metcalf, Ginger A. ;

Ng, Brian ;

Milosavljevic, Aleksandar ;

Gonzalez-Garay, Manuel L. ;

Osborne, John R. ;

Meyer, Rick ;

Shi, Xiaoqi ;

Tang, Yuzhu ;

Koboldt, Daniel C. ;

Lin, Ling ;

Abbott, Rachel ;

Miner, Tracie L. ;

Pohl, Craig ;

Fewell, Ginger ;

Haipek, Carrie ;

Schmidt, Heather ;

Dunford-Shore, Brian H. ;

Kraja, Aldi ;

Crosby, Seth D. ;

Sawyer, Christopher S. .

NATURE, 2008, 455 (7216) :1069-1075

[7] Lung cancer and lung stem cells - Strange bedfellows? [J].

Giangreco, Adam ;

Groot, Karen R. ;

Janes, Sam M. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2007, 175 (06) :547-553

[8] Stem cells are dispensable for lung homeostasis but restore airways after injury [J].

Giangreco, Adam ;

Arwerta, Esther N. ;

Rosewell, Ian R. ;

Snyder, Joshua ;

Watt, Fiona M. ;

Stripp, Barry R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (23) :9286-9291

[9] MORE POWERFUL PROCEDURES FOR MULTIPLE SIGNIFICANCE TESTING [J].

HOCHBERG, Y ;

BENJAMINI, Y .

STATISTICS IN MEDICINE, 1990, 9 (07) :811-818

[10] Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras [J].

Jackson, EL ;

Willis, N ;

Mercer, K ;

Bronson, RT ;

Crowley, D ;

Montoya, R ;

Jacks, T ;

Tuveson, DA .

GENES & DEVELOPMENT, 2001, 15 (24) :3243-3248

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