CSF and MRI markers independently contribute to the diagnosis of Alzheimer's disease

被引:82
作者
Schoonenboom, Niki S. M. [1 ]
van der Flier, Wiesje M. [1 ]
Blankenstein, Marinus A. [2 ]
Bouwman, Femke H. [1 ]
Van Kamp, Gerard J. [1 ]
Barkhof, Frederik [3 ]
Scheltens, Philip [1 ]
机构
[1] Vrije Univ Amsterdam Med Ctr, Dept Neurol, Alzheimers Ctr, NL-1081 HV Amsterdam, Netherlands
[2] Vrije Univ Amsterdam Med Ctr, Dept Clin Chem, Alzheimers Ctr, NL-1081 HV Amsterdam, Netherlands
[3] Vrije Univ Amsterdam Med Ctr, Dept Radiol, Alzheimers Ctr, NL-1081 HV Amsterdam, Netherlands
关键词
alzheimer's disease; CSF and MRI markers; A beta 42; tau and phosphorylated tau;
D O I
10.1016/j.neurobiolaging.2006.11.018
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: Decreased amyloid P (1-42) (A beta 42) and increased (phosphorylated) tau in cerebrospinal fluid (CSF) are considered to be a reflection of plaques, tangles, and neuronal degeneration in Alzheimer's disease (AD). Atrophy of the medial temporal lobe (MTA) 011 magnetic resonance imaging (MRI) reflects neuronal loss in this area. Objective: To compare diagnostic accuracy of CSF biomarkers and NITA in AD versus controls. Methods: A beta 42, tau and tau phosphorylated at threonine 181 (Ptau-181) were measured in CSF from 61 AD patients and 32 controls by sandwich enzyme-linked immunosorbent assay. A CSF biomarker profile for AD was constructed. NITA was rated visually on MRI. Results: When AD patients and controls were evaluated separately, no correlations were present between the CSF markers and NITA score. Both NITA and CSF biomarker profile were independently associated with the diagnosis AD (NITA: OR (95% Cl) = 28 (3-239); CSF biomarker profile: OR (95% Q = 57 (13-262)). Among individuals younger than 65 years old and without NITA 60% suffered AD, and the finding of an abnormal CSF biomarker profile was limited to AD patients only. Conclusions: NITA and CSF biomarkers seem to be of incremental value for the diagnosis AD. CSF analysis is most sensitive in the absence of NITA, and especially among early-onset AD patients. (c) 2007 Published by Elsevier Inc.
引用
收藏
页码:669 / 675
页数:7
相关论文
共 37 条
[1]  
Alzheimers Assoc, 1998, NEUROBIOL AGING, V19, P109
[2]   Cerebrospinal fluid β-amyloid(1-42) in Alzheimer disease -: Differences between early- and late-onset Alzheimer disease and stability during the course of disease [J].
Andreasen, N ;
Hesse, C ;
Davidsson, P ;
Minthon, L ;
Wallin, A ;
Winblad, B ;
Vanderstichele, H ;
Vanmechelen, E ;
Blennow, K .
ARCHIVES OF NEUROLOGY, 1999, 56 (06) :673-680
[3]   CSF markers for incipient Alzheimer's disease [J].
Blennow, K ;
Hampel, H .
LANCET NEUROLOGY, 2003, 2 (10) :605-613
[4]  
Bobinski M, 2000, NEUROSCIENCE, V95, P721
[5]   CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive impairment [J].
Bouwman, F. H. f ;
Schoonenboom, S. N. M. ;
van der Flier, W. M. ;
van Elk, E. J. ;
Kok, A. ;
Barkhof, F. ;
Blankenstein, M. A. ;
Scheltens, Ph .
NEUROBIOLOGY OF AGING, 2007, 28 (07) :1070-1074
[6]   Cerebrospinal fluid tau and β-amyloid -: How well do these biomarkers reflect autopsy-confirmed dementia diagnoses? [J].
Clark, CM ;
Xie, S ;
Chittams, J ;
Ewbank, D ;
Peskind, E ;
Galasko, D ;
Morris, JC ;
McKeel, DW ;
Farlow, M ;
Weitlauf, SL ;
Quinn, J ;
Kaye, J ;
Knopman, D ;
Arai, H ;
Doody, RS ;
DeCarli, C ;
Leight, S ;
Lee, VMY ;
Trojanowski, JQ .
ARCHIVES OF NEUROLOGY, 2003, 60 (12) :1696-1702
[7]  
Csernansky JG, 2004, ALZ DIS ASSOC DIS, V18, P190
[8]   Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment [J].
de Leon, MJ ;
DeSanti, S ;
Zinkowski, R ;
Mehta, PD ;
Pratico, D ;
Segal, S ;
Rusinek, H ;
Li, J ;
Tsui, W ;
Saint Louis, LA ;
Clark, CM ;
Tarshish, C ;
Li, Y ;
Lair, L ;
Javier, E ;
Rich, K ;
Lesbre, P ;
Mosconi, L ;
Reisberg, B ;
Sadowski, M ;
DeBernadis, JF ;
Kerkman, DJ ;
Harnpel, H ;
Wahlund, LO ;
Davies, P .
NEUROBIOLOGY OF AGING, 2006, 27 (03) :394-401
[9]   MRI and CSF studies in the early diagnosis of Alzheimer's disease [J].
de Leon, MJ ;
DeSanti, S ;
Zinkowski, R ;
Mehta, PD ;
Pratico, D ;
Segal, S ;
Clark, C ;
Kerkman, D ;
DeBernardis, J ;
Li, J ;
Lair, L ;
Reisberg, B ;
Tsui, W ;
Rusinek, H .
JOURNAL OF INTERNAL MEDICINE, 2004, 256 (03) :205-223
[10]  
FOLSTEIN MF, 1983, ARCH GEN PSYCHIAT, V40, P812