Enantiopure β-methoxy carboxyl derivatives from a chiral titanium enolate and dimethyl acetals

被引：27

作者：

Cosp, A ^{[1
]}

Romea, P ^{[1
]}

Urpí, F ^{[1
]}

Vilarrasa, J ^{[1
]}

机构：

[1] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Catalonia, Spain

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 28期

关键词：

acetals; aldol reactions; asymmetric reactions; enolates;

D O I：

10.1016/S0040-4039(01)00829-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lewis acid-mediated reaction of the titanium enolate arising from (S)-N-acetyl-4-isopropyl-1,3-thiazolidine-2-thione with dimethyl acetals furnishes beta -methoxy carboxyl adducts in good yields and stereoselectives. The adducts can be, in turn, transformed into a wide range of enantiopure alpha -unsubstituted beta -methoxy carboxyl derivatives in excellent yields. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：4629 / 4631

页数：3

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