High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users

被引：85

作者：

Kim, DJ

Roh, S

Kim, Y ^{[1
]}

Yoon, SJ

Lee, HK

Han, CS

Kim, YK ^{[1
]}

机构：

[1] Korea Univ, Coll Med, Dept Psychiat, Seoul 136701, South Korea

[2] Catholic Univ Korea, Korea Univ, Ansan Hosp, Coll Med,Dept Psychiat, Seoul 425020, South Korea

[3] Hanyang Univ, Coll Med, Dept Neuropsychiat, Seoul 133791, South Korea

来源：

NEUROSCIENCE LETTERS | 2005年 / 388卷 / 02期

关键词：

BDNF; methamphetamine; ELISA; dopamine; neurotoxicity;

D O I：

10.1016/j.neulet.2005.06.042

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3 pg/ml versus 1352.6 pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：112 / 115

页数：4

共 30 条

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