Membrane channel activity and translocation of tetanus and botulinum neurotoxins

被引：21

作者：

Lebeda, FJ

Singh, BR ^{[1
]}

机构：

[1] USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Toxinol Div, Frederick, MD 21702 USA

[2] Univ Massachusetts, Dept Chem, N Dartmouth, MA 02747 USA

来源：

JOURNAL OF TOXICOLOGY-TOXIN REVIEWS | 1999年 / 18卷 / 01期

基金：

美国国家卫生研究院;

关键词：

protein-membrane interactions; protein structure; oligomerization; diphtheria toxin; anthrax protective antigen; Staphylococcus aureus alpha-hemolysin;

D O I：

10.3109/15569549909036017

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

This review centers on the structure and function of ionic channels formed by clostridial neurotoxins. Questions regarding their structure, the pathways for their formation, and their role in translocating the toxic moiety across an endocytotic membrane are discussed.

引用

页码：45 / 76

页数：32

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