A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration

被引：204

作者：

Das, Soumyashree ^{[1
]}

Goldstone, Andrew B. ^{[2
]}

Wang, Hanjay ^{[2
]}

Farry, Justin ^{[2
]}

D'Amato, Gaetano ^{[1
]}

Paulsen, Michael J. ^{[2
]}

Eskandari, Anahita ^{[2
]}

Hironaka, Camille E. ^{[2
]}

Phansalkar, Ragini ^{[1
,5
]}

Sharma, Bikram ^{[6
]}

Rhee, Siyeon ^{[1
]}

Shamskhou, Elya Ali ^{[4
]}

Agalliu, Dritan ^{[7
,8
,9
]}

Perez, Vinicio de Jesus ^{[4
]}

Woo, Y. Joseph ^{[2
]}

Red-Horse, Kristy ^{[1
,3
]}

机构：

[1] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Cardiothorac Surg, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA

[5] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[6] Ball State Univ, Dept Biol, Muncie, IN 47306 USA

[7] Columbia Univ, Dept Neurol, Irving Med Ctr, New York, NY 10032 USA

[8] Columbia Univ, Dept Pathol & Cell Biol, Irving Med Ctr, New York, NY 10032 USA

[9] Columbia Univ, Dept Pharmacol, Irving Med Ctr, New York, NY 10032 USA

来源：

CELL | 2019年 / 176卷 / 05期

关键词：

CELL-DERIVED FACTOR-1-ALPHA; ENDOTHELIAL GROWTH-FACTOR; BLOOD-BRAIN-BARRIER; MYOCARDIAL-INFARCTION; CARDIAC REGENERATION; CORONARY VASCULATURE; ASSOCIATION ANALYSIS; FACTOR-I; CXCL12; ANGIOGENESIS;

D O I：

10.1016/j.cell.2018.12.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Collateral arteries are an uncommon vessel subtype that can provide alternate blood flow to preserve tissue following vascular occlusion. Some patients with heart disease develop collateral coronary arteries, and this correlates with increased survival. However, it is not known how these collaterals develop or how to stimulate them. We demonstrate that neonatal mouse hearts use a novel mechanism to build collateral arteries in response to injury. Arterial endothelial cells (ECs) migrated away from arteries along existing capillaries and reassembled into collateral arteries, which we termed "artery reassembly''. Artery ECs expressed CXCR4, and following injury, capillary ECs induced its ligand, CXCL12. CXCL12 or CXCR4 deletion impaired collateral artery formation and neonatal heart regeneration. Artery reassembly was nearly absent in adults but was induced by exogenous CXCL12. Thus, understanding neonatal regenerative mechanisms can identify pathways that restore these processes in adults and identify potentially translatable therapeutic strategies for ischemic heart disease.

引用

页码：1128 / +

页数：33

共 65 条

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Stromal cell-derived factor-1α plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury [J].