The identification of cyclooxygenase-1 inhibitors from 4-thiazolidinone combinatorial libraries

被引：106

作者：

Look, GC

Schullek, JR

Holmes, CP

Chinn, JP

Gordon, EM

Gallop, MA

机构：

[1] Affymax Research Institute, Santa Clara, CA 95051

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 06期

关键词：

D O I：

10.1016/0960-894X(96)00097-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three 4-thiazolidinone libraries, each containing up to 540 compounds, were prepared and assayed for inhibition of the enzyme cyclooxygenase-l (COX-1). Deconvolution analysis led to the identification of a compound that is equipotent with the commercial COX-1 inhibitors ibuprofen and phenylbutazone.

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页码：707 / 712

页数：6

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