Glycolytic pathway intermediates activate cardiac ryanodine receptors

被引:30
作者
Kermode, H [1 ]
Chan, WM [1 ]
Williams, AJ [1 ]
Sitsapesan, R [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Sch Med, NHLI, London SW3 6LY, England
关键词
ryanodine receptor; Ca2+-release channel; sarcoplasmic reticulum; glycolysis; ischemia; fructose-1,6-diphosphate;
D O I
10.1016/S0014-5793(98)00725-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
During myocardial ischaemia and reperfusion, enhancement of glycolytic activity occurs and this may lead to fluctuating levels of glycolytic intermediates [1-3]. We demonstrate that sugar phosphate intermediates of glycolysis, particularly fructose-1,6-diphosphate (FDP; 100 mu M-10 mM), can activate sheep cardiac ryanodine receptor (RBR) channels incorporated into bilayers (open probability (Po) increases up to approximately 0.6) and stimulate [H-3]ryanodine binding (>200%) to isolated cardiac sarcoplasmic reticulum (SR) membrane vesicles. The relative effectiveness of the sugar phosphates in stimulating [H-3]ryanodine binding and increasing the Po of the channels mas FDP > glucose-1-phosphate (G-6-P) > fructose-6-phosphate (F-6-P) > glucose-6-phosphate (G-6-P). These novel properties of the sugar phosphate compounds indicate that changes in glycolytic flux may influence the release of SR Ca2+ by modulating RyR channel gating. (C) 1998 Federation of European Biochemical Societies.
引用
收藏
页码:59 / 62
页数:4
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