Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates

被引：79

作者：

Balaz, M ^{[1
]}

Holmes, AE ^{[1
]}

Benedetti, M ^{[1
]}

Rodriguez, PC ^{[1
]}

Berova, N ^{[1
]}

Nakanishi, K ^{[1
]}

Proni, G ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 12期

关键词：

D O I：

10.1021/ja043373z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The preparation and circular dichroic (CD) studies of self-complimentary 8-mer DNA sequences with a porphyrin at the 3- end are presented. Electronic interaction between the two porphyrins (the interchromophoric distance is in the range of 28-40 Å), attached to both ends of the double-stranded helix, gives rise to a long-range exciton-coupled CD in the visible region (400-450 nm). The porphyrin chromophores act as sensitive probes of geometrical changes in the DNA backbone and sensitively reflect the double-strand to single-strand transition. This study demonstrates the possibility of using exciton-coupled porphyrin CDs for conformational studies of DNA. Copyright © 2005 American Chemical Society.

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页码：4172 / 4173

页数：2

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