DNA alkylation sites of nitrogen mustards conjugated to polyamines and their implications for polyamine-DNA interactions

被引：13

作者：

Cullis, PM ^{[1
]}

Merson-Davies, L

Sutcliffe, MJ

Weaver, R

机构：

[1] Univ Leicester, Dept Chem, Leicester LE1 7RH, Leics, England

[2] Univ Leicester, Ctr Mechanisms Human Tox, Leicester LE1 7RH, Leics, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 16期

关键词：

D O I：

10.1039/a803399d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polyamines conjugated to the nitrogen mustard chlorambucil increase the efficiency of DNA alkylation at N-7 Of guanine by factors in the range 10(3) to 10(4); the sequence selectivity of this alkylation (the alkylation 'finger-print') is largely unchanged, which is consistent with flexible, electrostatic binding and incompatible with tight, sequence-specific binding of the polyamine moiety.

引用

页码：1699 / 1700

页数：2

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