Fertility preservation for young patients with cancer: who is at risk and what can be offered?

被引：573

作者：

Wallace, WHB

Anderson, RA

Irvine, DS

机构：

[1] Univ Edinburgh, Dept Obstet & Gynaecol, Edinburgh EH8 9YL, Midlothian, Scotland

[2] Univ Edinburgh, Div Reprod & Dev Sci, Edinburgh EH8 9YL, Midlothian, Scotland

[3] MRC, Ctr Reprod Biol, Reprod Sci Unit, Edinburgh EH3 9EW, Midlothian, Scotland

[4] Univ Edinburgh, Dept Child Life & Hlth, Edinburgh EH8 9YL, Midlothian, Scotland

来源：

LANCET ONCOLOGY | 2005年 / 6卷 / 04期

关键词：

D O I：

10.1016/S1470-2045(05)70092-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Estimates suggest that by 2010, one in 715 people in the UK will have survived cancer during childhood. With increasing numbers of children cured, attention has focused on their quality of life. We discuss the causes of impaired fertility after cancer treatment in young people, and outline which patients are at risk and how their gonadal function should be assessed. With the report of a livebirth after orthotopic transplantation of cryopreserved ovarian tissue and the continued development of intracytoplasmic sperm injection for men with poor sperm quality, we assess established and experimental strategies to protect or restore fertility, and discuss the ethical and legal issues that arise.

引用

收藏

页码：209 / 218

页数：10

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