Biting the hand that feeds: Rpn4-dependent feedback regulation of proteasome function

被引:56
作者
Dohmen, R. Jurgen [1 ]
Willers, Imke [1 ]
Marques, Antonio J. [1 ]
机构
[1] Univ Cologne, Inst Genet, D-50674 Cologne, Germany
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2007年 / 1773卷 / 11期
关键词
proteasome; ubiquitin; Rpn4; Ubr2; Ubc2; Yap I; Pdr3; HSF;
D O I
10.1016/j.bbamcr.2007.05.015
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The 26S proteasome of eukaryotic cells mediates ubiquitin-dependent as well as ubiquitin-independent degradation of proteins in many regulatory processes as well as in protein quality control. The proteasome itself is a dynamic complex with varying compositions and interaction partners. Studies in Saccharomyces cerevisiae have revealed that expression of proteasome subunit genes is coordinately controlled by the Rpn4 transcriptional activator. The cellular level of Rpn4 itself is subject to a complex regulation, which, aside of a transcriptional control of its gene, intriguingly involves ubiquitin-dependent as well as ubiquitin-independent control of its stability by the proteasome. A novel study by Ju et al. [D. Ju, H. Yu, X. Wang, Y. Xie, Ubiquitin-mediated degradation of Rpn4 is controlled by a phosphorylation-dependent ubiquitylation signal, Biochim. Biophys. Acta (in press), doi: 10.1016/j.bbamcr.2007.04.012] now revealed another level of complexity by showing that phosphorylation of a specific serine residue in Rpn4 is required for its efficient targeting by the Ubr2 ubiquitin ligase. (C) 2007 Elsevier B.V All rights reserved.
引用
收藏
页码:1599 / 1604
页数:6
相关论文
共 54 条
[1]   The proteasome: A suitable antineoplastic target [J].
Adams, J .
NATURE REVIEWS CANCER, 2004, 4 (05) :349-360
[2]   The proteasome:: Paradigm of a self-compartmentalizing protease [J].
Baumeister, W ;
Walz, J ;
Zühl, F ;
Seemuller, E .
CELL, 1998, 92 (03) :367-380
[3]   Identification and characterization of a mammalian protein interacting with 20S proteasome precursors [J].
Burri, L ;
Höckendorff, J ;
Boehm, U ;
Klamp, T ;
Dohmen, RJ ;
Lévy, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (19) :10348-10353
[4]   Proteasomes: Machines for all reasons [J].
DeMartino, George N. ;
Gillette, Thomas G. .
CELL, 2007, 129 (04) :659-662
[5]   Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome [J].
Elsasser, S ;
Chandler-Militello, D ;
Müller, B ;
Hanna, J ;
Finley, D .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (26) :26817-26822
[6]   Blm3 is part of nascent proteasomes and is involved in a late stage of nuclear proteasome assembly [J].
Fehlker, M ;
Wendler, P ;
Lehmann, A ;
Enenkel, C .
EMBO REPORTS, 2003, 4 (10) :959-963
[7]   Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle [J].
Finley, D ;
Tanaka, K ;
Mann, C ;
Feldmann, H ;
Hochstrasser, M ;
Vierstra, R ;
Johnston, S ;
Hampton, R ;
Haber, J ;
McCusker, J ;
Silver, P ;
Frontali, L ;
Thorsness, P ;
Varshavsky, A ;
Byers, B ;
Madura, K ;
Reed, SI ;
Wolf, D ;
Jentsch, S ;
Sommer, T ;
Baumeister, W ;
Goldberg, A ;
Fried, V ;
Rubin, DM ;
Glickman, MH ;
Toh-E, A .
TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (07) :244-245
[8]   Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341 [J].
Fleming, JA ;
Lightcap, ES ;
Sadis, S ;
Thoroddsen, V ;
Bulawa, CE ;
Blackman, RK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) :1461-1466
[9]   Son1p is a component of the 26S proteasome of the yeast Saccharomyces cerevisiae [J].
Fujimuro, M ;
Tanaka, K ;
Yokosawa, H ;
Toh-e, A .
FEBS LETTERS, 1998, 423 (02) :149-154
[10]   A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3 [J].
Glickman, MH ;
Rubin, DM ;
Coux, O ;
Wefes, I ;
Pfeifer, G ;
Cjeka, Z ;
Baumeister, W ;
Fried, VA ;
Finley, D .
CELL, 1998, 94 (05) :615-623