Exploring the risk factors of preterm birth using data mining

Preterm birth is the leading cause of perinatal morbidity and mortality, but a precise mechanism is still unknown. Hence, the goal of this study is to explore the risk factors of preterm using data mining with neural network and decision tree C5.0. The original medical data were collected from a prospective pregnancy cohort by a professional research group in National Taiwan University. Using the nest case-control study design, a total of 910 mother-child dyads were recruited from 14,551 in the original data. Thousands of variables are examined in this data including basic characteristics, medical history, environment, and occupation factors of parents, and variables related to infants. The results indicate that multiple birth, hemorrhage during pregnancy, age, disease, previous preterm history, body weight before pregnancy and height of pregnant women, and paternal life style risk factors related to drinking and smoking are the important risk factors of preterm birth. Hence, the findings of our study will be useful for parents, medical staff, and public health workers in attempting to detect high risk pregnant women and provide intervention early to reduce and prevent preterm birth. (C) 2010 Elsevier Ltd. All rights reserved.