Antibiotic resistance and single-nucleotide polymorphism cluster grouping type in a multinational sample of resistant Mycobacterium tuberculosis isolates

被引：12

作者：

Brimacombe, M.

Hazbon, M.

Motiwala, A. S.

Alland, D.

机构：

[1] Univ Med & Dent New Jersey, Dept Prevent Med & Community Hlth, New Jersey Med Sch, Union, NJ 07083 USA

[2] Univ Med & Dent New Jersey, Dept Med, New Jersey Med Sch, Union, NJ 07083 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 11期

关键词：

D O I：

10.1128/AAC.00619-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A single-nucleotide polymorphism-based cluster grouping (SCG) classification system for Mycobacterium tuberculosis was used to examine antibiotic resistance type and resistance mutations in relationship to specific evolutionary lineages. Drug resistance and resistance mutations were seen across all SCGs. SCG-2 had higher proportions of katG codon 315 mutations and resistance to four drugs.

引用

页码：4157 / 4159

页数：3

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