Relations of serum interleukin 18 levels to serum lipid and glucose concentrations in an apparently healthy adult population

被引：30

作者：

Olusi, SO

Al-Awadhi, A

Abraham, M

机构：

[1] Kuwait Univ, Fac Med, Dept Pathol, Safat 13110, Kuwait

[2] Kuwait Univ, Fac Med, Dept Med, Safat 13110, Kuwait

来源：

HORMONE RESEARCH | 2003年 / 60卷 / 01期

关键词：

carbohydrate; glucose; interleukin; 18; lipids;

D O I：

10.1159/000070824

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: To investigate the associations between serum interleukin (IL) 18 concentrations and indices of lipid and carbohydrate metabolism in healthy adults. Methods: Fasting serum concentrations of IL-18, glucose, total cholesterol, triglyceride, and high- and low-density lipoprotein cholesterols were measured in 570 apparently healthy adults. Results: Univariate linear and partial regression analyses showed that the serum IL-18 concentration was positively correlated with serum triglyceride and glucose concentrations in both obese and diabetic subjects after controlling for the confounding effects of age, sex, and body mass index. Conclusion: IL-18 may be associated with obesity and glucose intolerance. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：29 / 33

页数：5

共 28 条

[1] Airway epithelium expresses interleukin-18 [J].

Cameron, LA ;

Taha, RA ;

Tsicopoulos, A ;

Kurimoto, M ;

Olivenstein, R ;

Wallaert, B ;

Minshall, EM ;

Hamid, QA .

EUROPEAN RESPIRATORY JOURNAL, 1999, 14 (03) :553-559

[2] Leptin: The tale of an obesity gene [J].

Caro, JF ;

Sinha, MK ;

Kolaczynski, JW ;

Zhang, PL ;

Considine, RV .

DIABETES, 1996, 45 (11) :1455-1462

[3]

Conti B, 1997, J BIOL CHEM, V272, P2035

[4] Cultures of astrocytes and microglia express interleukin 18 [J].

Conti, B ;

Park, LCH ;

Calingasan, NY ;

Kim, Y ;

Kim, H ;

Bae, Y ;

Gibson, GE ;

Joh, TH .

MOLECULAR BRAIN RESEARCH, 1999, 67 (01) :46-52

[5] Is obesity an inflammatory condition? [J].

Das, UN .

NUTRITION, 2001, 17 (11-12) :953-966

[6]

FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499

[7] A new way of looking at obesity [J].

Hill, JO .

NUTRITION, 2001, 17 (11-12) :975-976

[8] THE EXPRESSION OF TUMOR-NECROSIS-FACTOR IN HUMAN ADIPOSE-TISSUE - REGULATION BY OBESITY, WEIGHT-LOSS, AND RELATIONSHIP TO LIPOPROTEIN-LIPASE [J].

KERN, PA ;

SAGHIZADEH, M ;

ONG, JM ;

BOSCH, RJ ;

DEEM, R ;

SIMSOLO, RB .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (05) :2111-2119

[9]

Kohno K, 1997, J IMMUNOL, V158, P1541

[10] Combined cardiac marker approach with adjunct two-dimensional echocardiography to diagnose acute myocardial infarction in the emergency department [J].

Levitt, MA ;

Promes, SB ;

Bullock, S ;

Disano, M ;

Young, GP ;

Gee, G ;

Peaslee, D .

ANNALS OF EMERGENCY MEDICINE, 1996, 27 (01) :1-7

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