antithrombotic therapy;
cancer patients;
low-molecular-weight heparin (LMWH);
survival;
venous thromboembolism;
D O I:
10.1016/S0305-7372(03)80006-3
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Thromboembolic disease has a negative impact on outcome in the cancer patient. Venous thromboembolism appears to be a more aggressive disease in patients with cancer who present with both a greater thrombus burden and more pronounced derangements of coagulation parameters than non-cancer patients with thrombosis. Retrospective analyses suggest that treatment of venous thromboembolism in cancer patients with low-molecular-weight heparin is associated with additional benefits in terms of their survival. The mechanism for this effect is unclear but may be attributable to a reduced incidence of recurrent thrombosis and fatal pulmonary embolism in those patients with underlying thrombosis. To investigate the potential of low-molecular-weight heparin to prolong survival in cancer patients without underlying thrombosis, a prospective trial (FAMOUS) has evaluated the effect of treatment with the low-molecular-weight heparin dalteparin for 1 year in terms of survival of patients with advanced cancer and no underlying thrombosis. (C) 2003 Elsevier Science Ltd. All rights reserved.
机构:Univ Calif San Diego, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
Borsig, L
Wong, R
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机构:Univ Calif San Diego, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
Wong, R
Feramisco, J
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机构:Univ Calif San Diego, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
Feramisco, J
Nadeau, DR
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机构:Univ Calif San Diego, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
Nadeau, DR
Varki, NM
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机构:Univ Calif San Diego, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
Varki, NM
Varki, A
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h-index: 0
机构:
Univ Calif San Diego, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
机构:
UNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADAUNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADA
GREEN, D
HULL, RD
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h-index: 0
机构:
UNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADAUNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADA
HULL, RD
BRANT, R
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADAUNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADA
BRANT, R
PINEO, GF
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADAUNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADA
机构:Univ Calif San Diego, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
Borsig, L
Wong, R
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
Wong, R
Feramisco, J
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
Feramisco, J
Nadeau, DR
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
Nadeau, DR
Varki, NM
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
Varki, NM
Varki, A
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
机构:
UNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADAUNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADA
GREEN, D
HULL, RD
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADAUNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADA
HULL, RD
BRANT, R
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADAUNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADA
BRANT, R
PINEO, GF
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADAUNIV CALGARY, DIV GEN INTERNAL MED, CLIN TRIALS UNIT, CALGARY T2N 1N4, ALBERTA, CANADA