The immunomodulator FTY720 is phosphorylated and released from platelets

被引：33

作者：

Anada, Yoshihiro

Igarashi, Yasuyuki

Kihara, Akio

机构：

[1] Hokkaido Univ, Fac Pharmaceut Sci, Lab Biomembrane & Biofunct Chem, Kita Ku, Sapporo, Hokkaido 060, Japan

[2] Hokkaido Univ, Fac Adv Life Sci, Lab Biomembrane & Biofunct Chem, Sapporo, Hokkaido 0010021, Japan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2007年 / 568卷 / 1-3期

关键词：

FTY720; sphingosine; 1-phosphate; sphingolipid; immunomodulator; platelet;

D O I：

10.1016/j.ejphar.2007.04.053

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The novel immunomodulator FTY720 causes lymphocytes from peripheral blood to accumulate in lymphoid tissues. In vivo, FTY720 is phosphorylated to FTY720-P, which binds to the sphingosine 1-phosphate receptor SIP,. So far, it has been unclear where FTY720-P is produced. We demonstrate that platelets efficiently convert FTY720 to FTY720-P and release it into the extracellular space. This release is mostly independent of platelet activation, but is slightly increased upon thrombin stimulation. These results suggest that platelets are a major source of plasma FTY720-P, and that FTY720-P release is mediated by two different transporters. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：106 / 111

页数：6

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