Changes in flavonoid content and tyrosinase inhibitory activity in kenaf leaf extract after far-infrared treatment

被引：38

作者：

Rho, Ho Sik ^{[1
]}

Ahn, Soo Mi ^{[1
]}

Lee, Bum Chun ^{[2
]}

Kim, Myung Kyoo ^{[3
]}

Ghimeray, Amal Kumar ^{[4
]}

Jin, Cheng Wu ^{[4
]}

Cho, Dong Ha ^{[4
]}

机构：

[1] AmorePacific Corp, R&D Ctr, Kyonggi Do 449729, Yongin, South Korea

[2] Morechem Corp, R&D Ctr, Seoul 136713, South Korea

[3] Samkyung Costech Co Ltd, Suwon 443734, South Korea

[4] Kangwon Natl Univ, Coll Biomed Sci, Dept Biohlth Technol, Chunchon 200701, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 24期

关键词：

Kenaf leaf; Far-infrared irradiation; Kaempferitrin; Afzelin; alpha-Rhamnoisorobin; Kaempferol; Tyrosinase; HIBISCUS-CANNABINUS;

D O I：

10.1016/j.bmcl.2010.09.082

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The tyrosinase inhibitory activity of ethanolic extract of kenaf (Hibiscus cannabinus L.) leaf was evaluated before and after subjecting it to far-infrared (FIR) irradiation. The main component of the extract was analyzed as kaempferitrin (kaempferol-3,7-O-alpha-dirhamnoside). Prior to FIR irradiation, no inhibitory activity of the extract was detected in a tyrosinase assay. However, after FIR irradiation for 1 h at 60 degrees C, significant tyrosinase inhibitory activity (IC(50) = 3500 ppm) was observed in it. In HPLC analysis, derhamnosylation products (kaempferol, afzelin, and alpha-rhamnoisorobin) were detected. The inhibitory activity may be due to the existence of derhamnosylation products. This study demonstrated that FIR irradiation can be used as a convenient tool for deglycosylation of flavonoid glycoside. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：7534 / 7536

页数：3

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