Susceptibility profile of 200 bloodstream isolates of Candida spp. collected from Brazilian tertiary care hospitals

被引:21
作者
Colombo, AL
Nakagawa, Z
Valdetaro, F
Branchini, MLM
Kussano, EJU
Nucci, M
机构
[1] Univ Fed Sao Paulo, Div Infect Dis, BR-04023062 Sao Paulo, Brazil
[2] Hosp & Maternidade Santa Marcelina, Sao Paulo, Brazil
[3] Univ Estadual Campinas, Sao Paulo, Brazil
[4] Hosp Serv Estado Sao Paulo, Sao Paulo, Brazil
[5] Univ Fed Rio de Janeiro, Univ Hosp, Rio De Janeiro, Brazil
基金
巴西圣保罗研究基金会;
关键词
antifungal susceptibility; Candida spp; candidemia; fungemia; nosocomial infection;
D O I
10.1080/1369378031000137198
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
We evaluated the antifungal susceptibility profile of 200 recent bloodstream isolates of Candida spp. sequentially obtained from patients admitted to five tertiary care hospitals in Brazil. Isolates were identified by classical methods and the antifungal susceptibility profile was determined by the NCCLS microbroth assay method. Candida albicans was the most frequent species (41.5%), followed by C. tropicalis (24%) and C. parapsilosis (20.5%). The frequency of C. glabrata and C. krusei was low (nine and two isolates, respectively). Only three strains were resistant to fluconazole (two C. krusei and one C. glabrata) and only one was resistant to itraconazole (the same C. glabrata strain that was resistant to fluconazole). Two strains were considered susceptible dose-dependent (SDD) to fluconazole and 13 isolates (6.5%) were SDD to itraconazole. Overall, the MIC50 value of non-C. albicans isolates for fluconazole was two dilutions higher than that of C. albicans isolates, and for itraconazole was one dilution higher. Resistance to amphotericin B (MICgreater than or equal to2 mug ml(-1)) was observed in 2.5% of isolates (two strains of C. albicans, two of C. parapsilosis and one of C. krusei). This study showed that episodes of candidemia in Brazilian public hospitals are represented mainly by fluconazole-susceptible non-C. albicans species. This finding is probably related to the low use of fluconazole in these hospitals.
引用
收藏
页码:235 / 239
页数:5
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