Repairing injured peripheral nerves: Bridging the gap

被引：394

作者：

Deumens, Ronald ^{[1
,2
,5
]}

Bozkurt, Ahmet ^{[2
,3
]}

Meek, Marcel F. ^{[4
]}

Marcus, Marco A. E. ^{[1
,5
]}

Joosten, Elbert A. J. ^{[1
,5
]}

Weis, Joachim ^{[2
,5
]}

Brook, Gary A. ^{[2
,5
]}

机构：

[1] Maastricht Univ, Med Ctr, Dept Anesthesiol, NL-6229 HX Maastricht, Netherlands

[2] Rhein Westfal TH Aachen, Fac Med, Inst Neuropathol, Aachen, Germany

[3] Rhein Westfal TH Aachen, Fac Med, Dept Plast Surg Reconstruct & Hand Surg, Burn Ctr, Aachen, Germany

[4] Scheper Hosp Emmen, Dept Hand & Plast Surg, Emmen, Netherlands

[5] European Grad Sch Neurosci EURON, Maastricht, Netherlands

来源：

PROGRESS IN NEUROBIOLOGY | 2010年 / 92卷 / 03期

关键词：

Axon regeneration; Peripheral nerve injury; Nerve grafting; Autologous nerves; Neurodegeneration; Neuropathic pain; Nerve guides; Nerve repair; RAT SCIATIC-NERVE; ELECTRICAL-STIMULATION PROMOTES; AUTOLOGOUS SCHWANN-CELLS; FIBROBLAST-GROWTH-FACTOR; MAGNETICALLY ALIGNED COLLAGEN; POLY-EPSILON-CAPROLACTONE; ACELLULAR MUSCLE GRAFTS; ACID) POROUS CONDUITS; CATWALK GAIT ANALYSIS; MOTONEURONS IN-VIVO;

D O I：

10.1016/j.pneurobio.2010.10.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Peripheral nerve injuries that induce gaps larger than 1-2 cm require bridging strategies for repair. Autologous nerve grafts are still the gold standard for such interventions, although alternative treatments, as well as treatments to improve the therapeutic efficacy of autologous nerve grafting are generating increasing interest. Investigations are still mostly experimental, although some clinical studies have been undertaken. In this review, we aim to describe the developments in bridging technology which aim to replace the autograft. A multi-disciplinary approach is of utmost importance to develop and optimise treatments of the most challenging peripheral nerve injuries. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：245 / 276

页数：32

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