Neuroprotective effect of donepezil, a nicotinic acetylcholine-receptor activator, on cerebral infarction in rats

被引：49

作者：

Fujiki, M ^{[1
]}

Kobayashi, H ^{[1
]}

Uchida, S ^{[1
]}

Inoue, R ^{[1
]}

Ishii, K ^{[1
]}

机构：

[1] Oita Univ, Sch Med, Dept Neurosurg, Oita 8795593, Japan

来源：

BRAIN RESEARCH | 2005年 / 1043卷 / 1-2期

关键词：

donepezil; cerebral ischemia; middle cerebral artery occlusion; neuronal death; preconditioning; neuroprotection;

D O I：

10.1016/j.brainres.2005.02.063

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study evaluated the potential effect of donepezil, which is known as an acetylcholinesterase inhibitor used for treatment of Alzheimer's disease, against cerebral infarction induced by permanent left middle cerebral artery (MCA) occlusion. Donepezil was given orally in various regimens, prior to MCA occlusion in rats. Pretreatment with a single oral dose of donepezil (12 mg/kg), 2 h before ischemia, significantly attenuated cerebral infarction volume (165.5 +/- 105.3 vs. 377.1 +/- 48.5 mm(3); P < 0.05). These neuroprotective effects were prevented by coinjection with mecamylamine, a nicotinic acetylcholine-receptor (nAChR) antagonist, indicating that protection was mediated by nAChR activation. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：236 / 241

页数：6

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